THE ACUTE VERTEBRAL AUGMENTATION (AVERT) STUDY: PROTOCOL FOR A RANDOMISED CONTROLLED, FEASIBILITY TRIAL OF SPINAL MEDIAL BRANCH NERVE BLOCK IN HOSPITALISED OLDER PATIENTS WITH VERTEBRAL FRAGILITY FRACTURES

The Acute VertEbRal AugmentaTion (AVERT) study: protocol for a randomised controlled, feasibility trial of spinal medial branch nerve block in hospitalised older patients with vertebral fragility fractures

Introduction Body Vertebral fragility fractures (VFFs) are the most common type of osteoporotic fracture found in older people, resulting in increasing morbidity and excess mortality.These fractures can cause significant pain, requiring admission to hospital.Vertebroplasty (VP) is effective in reducing pain and allowing early mobilisation in hospit

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Exploring neuronal bistability at the depolarization block.

Many neurons display bistability--coexistence of two firing modes such as bursting and tonic spiking or tonic spiking and silence.Bistability has been proposed to endow neurons with richer forms of information processing in general and to be involved in short-term memory in particular by allowing a brief signal to elicit long-lasting changes in fir

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